2-Bromopropane → HCID 68715227, compound

HRID 29323Notes

Reaction equation

HRID 29323 reaction equation
[CH3:1][C:2]1[C:6]2[C:7]([OH:13])=[C:8]([CH2:11][CH3:12])[CH:9]=[CH:10][C:5]=2[O:4][C:3]=1[C:14]([O:16][CH2:17][CH3:18])=[O:15].Br[CH:20]([CH3:22])[CH3:21]>>[CH2:17]([O:16][C:14]([C:3]1[O:4][C:5]2[CH:10]=[CH:9][C:8]([CH2:11][CH3:12])=[C:7]([O:13][CH:20]([CH3:22])[CH3:21])[C:6]=2[C:2]=1[CH3:1])=[O:15])[CH3:18]

Participants

3

Reactant 2

HCID 63582-BromopropaneHCID 68711669Ethyl 3-methyl-4-hydroxy-5-ethylbenzofuran-2-carboxylate

Product 1

HCID 68715227HCID 68715227, compoundYield 89.7%

Procedure

According to the procedure of Example 86, Step 3 0.200 g (0.81 mmol) of 3-methyl-4-hydroxy-5-ethylbenzofuran carboxylic acid ethyl ester (Example 86, Step 2) and 0.379 mL (4.03 mmol) of 2-bromopropane gave 0.211 g of 5-ethyl-4-isopropoxy-3-methylbenzofuran-2-carboxylic acid ethyl ester after chromatography on silica gel eluting with ethyl acetate/hexanes (1:20).

Sources & evidence

ORD record
ord-028d37f88a364b38bbb8410a0bcb7819
Source dataset
uspto-grants-2008_09
Patent number
US07420001B2

Reaction notes

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