反应详情

To a solution of 160 mg of 4-ethoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester dissolved in 1 mL of THF was added 3 mL of LiOH solution (3.6 g LiOH/50 mL MeOH/50 mL H2O). The mixture was stirred at room temperature overnight. The solvents were removed under vacuum and the residue was dissolved in 5 mL of water. The solution was acidified and the resulting suspension was filtered. The solid product was dried under vacuum to give 130 mg (92% yield) of 4-ethoxy-3-methyl-benzofuran-2-carboxylic acid was obtained as white solid.

1. customThe solvents were removed under vacuum
2. dissolutionthe residue was dissolved in 5 mL of water
3. filtrationthe resulting suspension was filtered
4. customThe solid product was dried under vacuum