Methane → 3-[4-(4-Amino-3-fluorophenoxy)pyridin-2-yl]-1-methyl-1-(1-methylpiperidin-4-yl)urea

HRID 293677Notes

Reaction equation

HRID 293677 reaction equation
[C:43].[F:1][c:2]1[c:3]([NH:27][C:28](=[O:29])[O:30][CH2:31][c:32]2[cH:33][cH:34][cH:35][cH:36][cH:37]2)[cH:4][cH:5][c:6]([O:8][c:9]2[cH:10][c:11]([NH:15][C:16](=[O:17])[N:18]([CH:19]3[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]3)[CH3:26])[n:12][cH:13][cH:14]2)[cH:7]1.[O:38]1[CH2:39][CH2:40][CH2:41][CH2:42]1.[Pd:44]>>[F:1][c:2]1[c:3]([NH2:27])[cH:4][cH:5][c:6]([O:8][c:9]2[cH:10][c:11]([NH:15][C:16](=[O:17])[N:18]([CH:19]3[CH2:20][CH2:21][N:22]([CH3:25])[CH2:23][CH2:24]3)[CH3:26])[n:12][cH:13][cH:14]2)[cH:7]1

Participants

5

Reactant 4

HCID 297MethaneHCID 8028TetrahydrofuranHCID 23938PalladiumHCID 57677492Benzyl (2-fluoro-4-{2-[3-methyl-3-(1-methylpiperidin-4-yl)ureido]pyridin-4-yloxy}phenyl)carbamate

Product 1

HCID 231531123-[4-(4-Amino-3-fluorophenoxy)pyridin-2-yl]-1-methyl-1-(1-methylpiperidin-4-yl)urea

Sources & evidence

ORD record
ord-f1e84cad6ea24ddea856cef0d2d79d4d
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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