N-methyl-2-pyrrolidone → tert-butyl N-[1-(3-amino-5-bromo-1H-pyrrolo[2,3-b]pyridin-4-yl)piperidin-3-yl]-N-methylcarbamate
Reaction equation
[Br:1][c:2]1[c:3]([F:12])[c:4]2[c:5]([n:6][cH:7]1)[nH:8][cH:9][c:10]2[NH2:11].[CH2:28]([N:29]([CH:30]([CH3:31])[CH3:32])[CH:33]([CH3:34])[CH3:35])[CH3:36].[CH3:13][N:14]([C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH:22]1[CH2:23][NH:24][CH2:25][CH2:26][CH2:27]1.[CH3:37][N:38]1[CH2:39][CH2:40][CH2:41][C:42]1=[O:43]>>[Br:1][c:2]1[c:3]([N:24]2[CH2:23][CH:22]([N:14]([CH3:13])[C:15]([O:16][C:17]([CH3:18])([CH3:19])[CH3:20])=[O:21])[CH2:27][CH2:26][CH2:25]2)[c:4]2[c:5]([n:6][cH:7]1)[nH:8][cH:9][c:10]2[NH2:11]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-6c8029e46dc845c9bf06f1c2164dcedb
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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