Sodium Hydroxide → HCID 53229935, compound

HRID 29433Notes

Reaction equation

HRID 29433 reaction equation
C([O:3][C:4]([C:6]1[O:7][C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1)=[O:5])C.[OH-].[Na+:16]>C1COCC1>[Na+:16].[O:7]1[C:8]2[CH:14]=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=[C:6]1[C:4]([O-:5])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 14220914Ethyl 1,3-benzoxazole-2-carboxylate

Product 1

HCID 53229935HCID 53229935, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To benzoxazole-2-carboxylic acid ethyl ester (437 mg, 4 mmol) was added 2 mL of THF and 4 mL of NaOH solution (2N in MeOH). The reaction mixture was stirred at room temperature overnight. The suspension was filtered and the solid was dried under vacuum to give 160 mg of benzoxazole-2-carboxylic acid sodium salt as an off-white solid.

Workup

  1. filtrationThe suspension was filtered
  2. customthe solid was dried under vacuum

Sources & evidence

ORD record
ord-b1e2bb31eee4497d91fc070369855224
Source dataset
uspto-grants-2008_09
Patent number
US07420001B2

Reaction notes

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