1,4-Dioxane → 6-[3-(4-Fluoro-phenyl)-5-hydroxymethyl-isoxazol-4-ylmethoxy]-N-(2,2,3,3,3-pentafluoro-propyl)-nicotinamide
Reaction equation
[CH3:14][O:15][C:16]([c:17]1[cH:18][n:19][c:20]([O:23][CH2:24][c:25]2[c:26](-[c:32]3[cH:33][cH:34][c:35]([F:38])[cH:36][cH:37]3)[n:27][o:28][c:29]2[CH2:30][OH:31])[cH:21][cH:22]1)=[O:39].[CH3:1][Al:2]([CH3:3])[CH3:4].[F:5][C:6]([CH2:7][NH2:8])([C:9]([F:10])([F:11])[F:12])[F:13].[O:40]1[CH2:41][CH2:42][O:43][CH2:44][CH2:45]1>>[F:5][C:6]([CH2:7][NH:8][C:16](=[O:15])[c:17]1[cH:18][n:19][c:20]([O:23][CH2:24][c:25]2[c:26](-[c:32]3[cH:33][cH:34][c:35]([F:38])[cH:36][cH:37]3)[n:27][o:28][c:29]2[CH2:30][OH:31])[cH:21][cH:22]1)([C:9]([F:10])([F:11])[F:12])[F:13]Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-c362d05e59b5493c9d7cc367eb7817bc
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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