Sodium Hydroxide → 5-Methyl-benzooxazole-2-carboxylic acid sodium salt

HRID 29441Notes

Reaction equation

HRID 29441 reaction equation
C([O:3][C:4]([C:6]1[O:7][C:8]2[CH:14]=[CH:13][C:12]([CH3:15])=[CH:11][C:9]=2[N:10]=1)=[O:5])C.[OH-].[Na+:17]>C1COCC1>[Na+:17].[CH3:15][C:12]1[CH:13]=[CH:14][C:8]2[O:7][C:6]([C:4]([O-:5])=[O:3])=[N:10][C:9]=2[CH:11]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 687130605-Methyl-benzooxazole-2-carboxylic acid ethyl ester

Product 1

HCID 687130965-Methyl-benzooxazole-2-carboxylic acid sodium salt

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 5-methyl-benzooxazole-2-carboxylic acid ethyl ester (170 mg) was added 2 mL of THF, and 0.83 mL (2 eq) of sodium hydroxide solution (2N in MeOH). The reaction mixture was stirred at room temperature overnight. The suspension was filtered and the solid was dried under vacuum to give 144 mg of 5-methyl-benzooxazole-2-carboxylic acid sodium salt as an off-white solid.

Workup

  1. filtrationThe suspension was filtered
  2. customthe solid was dried under vacuum

Sources & evidence

ORD record
ord-2bcbbd2cb4ec4104b09d0eac7f1c2258
Source dataset
uspto-grants-2008_09
Patent number
US07420001B2

Reaction notes

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