Sodium Hydroxide → 857081-42-6

HRID 29445Notes

Reaction equation

HRID 29445 reaction equation
C([O:3][C:4]([C:6]1[S:7][C:8]2[CH:14]=[CH:13][C:12]([Cl:15])=[CH:11][C:9]=2[N:10]=1)=[O:5])C.[OH-].[Na+:17]>C1COCC1>[Na+:17].[Cl:15][C:12]1[CH:13]=[CH:14][C:8]2[S:7][C:6]([C:4]([O-:5])=[O:3])=[N:10][C:9]=2[CH:11]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 63357893Ethyl 5-chloro-1,3-benzothiazole-2-carboxylate

Product 1

HCID 68717138857081-42-6

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To 5-chloro-benzothiazole-2-carboxylic acid ethyl ester (200 mg, 0.83 mmol) was added 3 mL of THF, and 0.83 mL (2 eq) of NaOH solution (2N in MeOH). The reaction mixture was stirred at room temperature overnight. The suspension was filtered and the solid was dried under vacuum to give 170 mg of 5-chloro-benzothiazole-2-carboxylic acid sodium salt as an off-white solid.

Workup

  1. filtrationThe suspension was filtered
  2. customthe solid was dried under vacuum

Sources & evidence

ORD record
ord-fc3d1e80ce71433185d60e5556f9662d
Source dataset
uspto-grants-2008_09
Patent number
US07420001B2

Reaction notes

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