HRID2945

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID11534

Bromoacetonitrile

C2H2BrN

HCID24758

Sodium hydride

HNa

结构：CC(C)(C)c1cc(C=C2SCNC2=O)cc(C(C)(C)C)c1O

HCID130003

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)c1cc(C=C2SCN(CC#N)C2=O)cc(C(C)(C)C)c1O

HCID54120060

未命名化合物

收率 40.7%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

7.03 g of 5-[[3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl]methylene]-4-thiazolidinone and 2.64 g of bromoacetonitrile were reacted in the presence of 0.97 g of 60% sodium hydride in mineral oil and 330 ml of tetrahydrofuran. Work-up of the reaction mixture provided 3.21 g of the desired title product, m.p. 186°-188° C.