Hydrochloric Acid → 8-(2-Hydroxy-pyridin-3-yl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decan-1-one
Reaction equation
[CH3:1][O:2][c:3]1[n:4][cH:5][cH:6][cH:7][c:8]1[N:9]1[CH2:10][CH2:11][C:12]2([CH2:13][CH2:14][N:15]([c:18]3[cH:19][cH:20][c:21]([O:24][C:25]([F:26])([F:27])[F:28])[cH:22][cH:23]3)[C:16]2=[O:17])[CH2:29][CH2:30]1.[CH3:33][Si:34]([Cl:35])([CH3:36])[CH3:37].[CH3:44][C:45]#[N:46].[CH3:47][CH2:48][O:49][C:50]([CH3:51])=[O:52].[ClH:38].[I-:31].[Na+:32].[Na+:43].[S:39](=[O:40])([OH:41])[O-:42]>>[OH:2][c:3]1[n:4][cH:5][cH:6][cH:7][c:8]1[N:9]1[CH2:10][CH2:11][C:12]2([CH2:13][CH2:14][N:15]([c:18]3[cH:19][cH:20][c:21]([O:24][C:25]([F:26])([F:27])[F:28])[cH:22][cH:23]3)[C:16]2=[O:17])[CH2:29][CH2:30]1Participants
9
Reactant 8
Product 1
Sources & evidence
- ORD record
- ord-773c094781a24c09a5003101fc9bc77e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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