1,2-Dichloroethane → (6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

HRID 296402Notes

Reaction equation

HRID 296402 reaction equation
[Br:1][c:2]1[cH:3][n:4][c:5]2[n:6]([cH:7]1)[n:8][c:9]([C:11](=[O:12])[OH:13])[cH:10]2.[CH2:25]([Cl:26])[CH2:27][Cl:28].[CH3:14][CH:15]1[NH:16][CH2:17][CH2:18][c:19]2[cH:20][cH:21][cH:22][cH:23][c:24]21.[O:39]=[CH:40][N:41]([CH3:42])[CH3:43].[OH:29][n:30]1[c:31]2[c:32]([cH:33][cH:34][cH:35][cH:36]2)[n:37][n:38]1>>[Br:1][c:2]1[cH:3][n:4][c:5]2[n:6]([cH:7]1)[n:8][c:9]([C:11](=[O:13])[N:16]1[CH:15]([CH3:14])[c:24]3[c:19]([cH:20][cH:21][cH:22][cH:23]3)[CH2:18][CH2:17]1)[cH:10]2

Participants

6

Reactant 5

HCID 111,2-DichloroethaneHCID 6228DimethylformamideHCID 757711-HydroxybenzotriazoleHCID 922141-Methyl-1,2,3,4-tetrahydroisoquinolineHCID 7719386-Bromopyrazolo[1,5-a]pyrimidine-2-carboxylic acid

Product 1

HCID 24810370(6-Bromo-pyrazolo[1,5-a]pyrimidin-2-yl)-(1-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

Sources & evidence

ORD record
ord-a4ca36aa3fd34879bee5f978a19be347
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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