Dichloromethane → 5-Bromo-2-methylthiazole-4-carbonitrile

HRID 296551Notes

Reaction equation

HRID 296551 reaction equation
[Br:1][c:2]1[c:3]([C:8](=[O:9])[NH2:10])[n:4][c:5]([CH3:7])[s:6]1.[CH3:11][CH2:12][N:13]([CH2:14][CH3:15])[CH2:16][CH3:17].[Cl:31][CH2:32][Cl:33].[F:18][C:19]([F:20])([F:21])[C:22]([O:23][C:24](=[O:25])[C:26]([F:27])([F:28])[F:29])=[O:30]>>[Br:1][c:2]1[c:3]([C:8]#[N:10])[n:4][c:5]([CH3:7])[s:6]1

Participants

5

Reactant 4

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 9845Trifluoroacetic anhydrideHCID 685440505-Bromo-2-methyl-thiazole-4-carboxylic acid amide

Product 1

HCID 8493835-Bromo-2-methylthiazole-4-carbonitrile

Sources & evidence

ORD record
ord-fd3867cbf46f46dbb894148848a487c1
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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