反应详情

3-Bromomethylbenzofuran-2-carboxylic acid methyl ester (269 mg, 1 mmol) was dissolved in anhydrous DMF and added 2M dimethylamine/THF solution (1.5 ml, 3 mmol). After 1-2 h, the reaction was diluted with EtOAc and washed twice with saturated NaHCO3 (aq.) and brine. The organic extract over was dried over Na2SO4 and then concentrated in vacuo. The crude was purified on a silica gel column (5% MeOH in dichloromethane) to give 3-dimethylaminomethylbenzofuran-2-carboxylic acid methyl ester (131 mg).

1. washwashed twice with saturated NaHCO3 (aq.) and brine
2. extractionThe organic extract
3. dry with materialover was dried over Na2SO4
4. concentrationconcentrated in vacuo
5. customThe crude was purified on a silica gel column (5% MeOH in dichloromethane)