反应详情

N-hydroxy-4-[2-(3-dimethylaminobenzofuran-2-ylcarbonylamino)ethoxy]-benzamide (22.7 g, 0.057 mol) was suspended in 2-propanol (220 ml). 12 M HCl (5.2 ml, 0.063 mol) was added in one portion and the resulting mixture was heated to reflux. Water (44 ml) was added dropwise until a homogenous solution was obtained. The reaction mixture was allowed to cool and crystallize overnight. After cooling below 5° C. for one h, the crystals were filtered and washed with 2-propanol before being dried in vacuo to give the title compound (22.0 g) as a white solid.

1. temperaturethe resulting mixture was heated to reflux
2. customwas obtained
3. temperatureto cool
4. customcrystallize overnight
5. temperatureAfter cooling below 5° C. for one h
6. filtrationthe crystals were filtered
7. washwashed with 2-propanol
8. custombefore being dried in vacuo