反应详情

温度

200 °C

A mixture of tert-butylamine (18.0 mL, 171 mmol) and (chloromethyl)trimethylsilane (7.00 g, 57.1 mmol) was heated in a thick-walled glass tube at 200° C. overnight. After cooling to ambient temperature, the reaction mixture was poured into 1 N NaOH and extracted three times with diethyl ether. The combined organic extracts were washed with brine, dried (MgSO4), and the volatiles evaporated in vacuo. Distillation (atmospheric pressure; ˜135° C.) of the residual liquid gave the title compound 77 as a colorless liquid.

1. temperatureAfter cooling to ambient temperature
2. extractionextracted three times with diethyl ether
3. washThe combined organic extracts were washed with brine
4. dry with materialdried (MgSO4)
5. customthe volatiles evaporated in vacuo
6. distillationDistillation (atmospheric pressure; ˜135° C.) of the residual liquid