Dimethyl Sulfoxide → 2-Nitro-5-(piperidin-1-yl)pyridine

HRID 297497Notes

Reaction equation

HRID 297497 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([N+:8](=[O:9])[O-:10])[n:6][cH:7]1.[C:11](=[O:12])([O-:13])[O-:14].[CH2:17]1[CH2:18][CH2:19][NH:20][CH2:21][CH2:22]1.[CH2:24]([N+:25]([CH2:26][CH2:27][CH2:28][CH3:29])([CH2:30][CH2:31][CH2:32][CH3:33])[CH2:34][CH2:35][CH2:36][CH3:37])[CH2:38][CH2:39][CH3:40].[CH3:41][S:42]([CH3:43])=[O:44].[CH3:45][CH2:46][O:47][C:48](=[O:49])[CH3:50].[I-:23].[K+:15].[K+:16]>>[c:2]1([N:20]2[CH2:19][CH2:18][CH2:17][CH2:22][CH2:21]2)[cH:3][cH:4][c:5]([N+:8](=[O:9])[O-:10])[n:6][cH:7]1

Participants

9

Reactant 8

HCID 679Dimethyl SulfoxideHCID 813Potassium Cation2×HCID 8082PiperidineHCID 8857Ethyl AcetateHCID 16028TetrabutylammoniumHCID 19660Carbonate IonHCID 30165Iodide IonHCID 8176205-Bromo-2-nitropyridine

Product 1

HCID 29279612-Nitro-5-(piperidin-1-yl)pyridine

Sources & evidence

ORD record
ord-461cab8de4d843a184f5049d211b7d77
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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