Tetrahydrofuran → 8-(2-Chloro-benzenesulfonyl)-2-(4-trifluoromethoxy-phenyl)-2,8-diaza-spiro[4.5]decane-1,7-dione
Reaction equation
[CH2:24]([Li:25])[CH2:26][CH2:27][CH3:28].[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[Cl:29][c:30]1[c:31]([S:36](=[O:37])(=[O:38])[Cl:39])[cH:32][cH:33][cH:34][cH:35]1.[F:1][C:2]([O:3][c:4]1[cH:5][cH:6][c:7]([N:10]2[C:11](=[O:21])[C:12]3([CH2:13][CH2:14]2)[CH2:15][C:16](=[O:20])[NH:17][CH2:18][CH2:19]3)[cH:8][cH:9]1)([F:22])[F:23]>>[F:1][C:2]([O:3][c:4]1[cH:5][cH:6][c:7]([N:10]2[C:11](=[O:21])[C:12]3([CH2:13][CH2:14]2)[CH2:15][C:16](=[O:20])[N:17]([S:36]([c:31]2[c:30]([Cl:29])[cH:35][cH:34][cH:33][cH:32]2)(=[O:37])=[O:38])[CH2:18][CH2:19]3)[cH:8][cH:9]1)([F:22])[F:23]Participants
5
Sources & evidence
- ORD record
- ord-a0dd1b0eb517467b9d998587226e1de9
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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