Tetrahydrofuran → tert-Butyl 4-[({[2-{[tert-butyl(diphenyl)silyl]oxy}-1-(hydroxymethyl)ethyl]amino}carbonyl)amino]piperidine-1-carboxylate

HRID 298677Notes

Reaction equation

HRID 298677 reaction equation
[Al+3:2].[C:7]([CH3:8])([CH3:9])([CH3:10])[O:11][C:12](=[O:13])[N:14]1[CH2:15][CH2:16][CH:17]([NH:20][C:21](=[O:22])[NH:23][CH:24]([CH2:25][O:26][Si:27]([c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)([c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[C:40]([CH3:41])([CH3:42])[CH3:43])[C:44](=[O:45])[OH:46])[CH2:18][CH2:19]1.[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3].[O:47]1[CH2:48][CH2:49][CH2:50][CH2:51]1>>[C:7]([CH3:8])([CH3:9])([CH3:10])[O:11][C:12](=[O:13])[N:14]1[CH2:15][CH2:16][CH:17]([NH:20][C:21](=[O:22])[NH:23][CH:24]([CH2:25][O:26][Si:27]([c:28]2[cH:29][cH:30][cH:31][cH:32][cH:33]2)([c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[C:40]([CH3:41])([CH3:42])[CH3:43])[CH2:44][OH:45])[CH2:18][CH2:19]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 690559673-[Tert-butyl(diphenyl)silyl]oxy-2-[[1-[(2-methylpropan-2-yl)oxycarbonyl]piperidin-4-yl]carbamoylamino]propanoic acid

Product 1

HCID 68568228tert-Butyl 4-[({[2-{[tert-butyl(diphenyl)silyl]oxy}-1-(hydroxymethyl)ethyl]amino}carbonyl)amino]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-5c04e045fc8c47f9b702a2ed87e6c464
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…