Tetrahydrofuran → 4-(4-Ethoxyphenyl)-2-fluoro-1-(4-fluoro-3-phenoxyphenyl)-4-methylpent-2-ene

HRID 298690Notes

Reaction equation

HRID 298690 reaction equation
[C:17]([O:18][CH2:21][C:22](=[CH:23][C:24]([CH3:25])([CH3:26])[c:27]1[cH:28][cH:29][c:30]([O:33][CH2:34][CH3:35])[cH:31][cH:32]1)[F:36])(=[O:19])[CH3:20].[F:1][c:2]1[c:3]([O:9][c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)[cH:4][c:5]([Br:8])[cH:6][cH:7]1.[Mg:16].[O:37]1[CH2:38][CH2:39][CH2:40][CH2:41]1>>[F:1][c:2]1[c:3]([O:9][c:10]2[cH:11][cH:12][cH:13][cH:14][cH:15]2)[cH:4][c:5]([CH2:21][C:22](=[CH:23][C:24]([CH3:25])([CH3:26])[c:27]2[cH:28][cH:29][c:30]([O:33][CH2:34][CH3:35])[cH:31][cH:32]2)[F:36])[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 5462224MagnesiumHCID 11076399Benzene, 4-bromo-1-fluoro-2-phenoxy-HCID 543050034-(4-Ethoxyphenyl)-2-fluoro-4-methylpent-2-enyl acetate

Product 1

HCID 539241884-(4-Ethoxyphenyl)-2-fluoro-1-(4-fluoro-3-phenoxyphenyl)-4-methylpent-2-ene

Sources & evidence

ORD record
ord-7349ae18fdc44416a9fe75f1d84710e6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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