4-(Bromomethyl)benzonitrile → 4-({[2-(3,5-Dichlorophenyl)-6-isopropylpyrimidin-4-yl]oxy}methyl)benzonitrile

HRID 29906Notes

Reaction equation

HRID 29906 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[N:14]=[C:13]([OH:15])[CH:12]=[C:11]([CH:16]([CH3:18])[CH3:17])[N:10]=2)[CH:5]=[C:6]([Cl:8])[CH:7]=1.[C:19]([C:21]1[CH:28]=[CH:27][C:24]([CH2:25]Br)=[CH:23][CH:22]=1)#[N:20]>>[Cl:8][C:6]1[CH:5]=[C:4]([C:9]2[N:14]=[C:13]([O:15][CH2:25][C:24]3[CH:27]=[CH:28][C:21]([C:19]#[N:20])=[CH:22][CH:23]=3)[CH:12]=[C:11]([CH:16]([CH3:18])[CH3:17])[N:10]=2)[CH:3]=[C:2]([Cl:1])[CH:7]=1

Participants

3

Reactant 2

HCID 869964-(Bromomethyl)benzonitrileHCID 178439458HCID 178439458, compound2×

Product 1

HCID 117415594-({[2-(3,5-Dichlorophenyl)-6-isopropylpyrimidin-4-yl]oxy}methyl)benzonitrile

Procedure

The title compound was prepared from 2-(3,5-dichloro-phenyl)-6-isopropyl-pyrimidin-4-ol (which was obtained in Intermediate 6) and 4-cyanobenzyl bromide according to Method A; LC retention time 4.22 min; MS: m/z (ESI) 398 (M+H).

Sources & evidence

ORD record
ord-52bde15521394de9bf08913cd8331e89
Source dataset
uspto-grants-2008_09
Patent number
US07423044B2

Reaction notes

Loading…