Dimethylformamide → Tris(1,1-dimethylethyl) 2-(2-chloro-5-fluoro-6-{[2-methyl-2-(4-morpholinyl)propyl]amino}-4-pyrimidinyl)-1,1,2-hydrazinetricarboxylate

HRID 299140Notes

Reaction equation

HRID 299140 reaction equation
[CH3:1][C:2]([CH2:3][NH2:4])([CH3:5])[N:6]1[CH2:7][CH2:8][O:9][CH2:10][CH2:11]1.[CH3:21][C:22]([CH3:23])([CH3:24])[O:25][C:26](=[O:27])[N:28]([N:29]([C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[c:37]1[n:38][c:39]([Cl:45])[n:40][c:41]([Cl:44])[c:42]1[F:43])[C:46](=[O:47])[O:48][C:49]([CH3:50])([CH3:51])[CH3:52].[CH:12]([N:13]([CH:14]([CH3:15])[CH3:16])[CH2:17][CH3:18])([CH3:19])[CH3:20].[O:53]=[CH:54][N:55]([CH3:56])[CH3:57]>>[CH3:1][C:2]([CH2:3][NH:4][c:41]1[n:40][c:39]([Cl:45])[n:38][c:37]([N:29]([N:28]([C:26]([O:25][C:22]([CH3:21])([CH3:23])[CH3:24])=[O:27])[C:46](=[O:47])[O:48][C:49]([CH3:50])([CH3:51])[CH3:52])[C:30](=[O:31])[O:32][C:33]([CH3:34])([CH3:35])[CH3:36])[c:42]1[F:43])([CH3:5])[N:6]1[CH2:7][CH2:8][O:9][CH2:10][CH2:11]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 81531DiisopropylethylamineHCID 19896412-Methyl-2-(morpholin-4-yl)propan-1-amineHCID 58000755Tris(1,1-dimethylethyl) 2-(2,6-dichloro-5-fluoro-4-pyrimidinyl)-1,1,2-hydrazinetricarboxylate

Product 1

HCID 86636980Tris(1,1-dimethylethyl) 2-(2-chloro-5-fluoro-6-{[2-methyl-2-(4-morpholinyl)propyl]amino}-4-pyrimidinyl)-1,1,2-hydrazinetricarboxylate

Sources & evidence

ORD record
ord-dc607c7c4c8d4219b2684d8921f486c5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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