Tetrahydrofuran → 5-Chloro-3-(2-fluoro-4-trimethylsilanyl-phenylamino)-pyrazine-2-carboxylic acid
Reaction equation
[CH2:34]1[O:35][CH2:36][CH2:37][CH2:38]1.[CH3:14][Si:15]([N-:16][Si:17]([CH3:18])([CH3:19])[CH3:20])([CH3:21])[CH3:22].[Cl:23][c:24]1[c:25]([C:31](=[O:32])[OH:33])[n:26][cH:27][c:28]([Cl:30])[n:29]1.[F:1][c:2]1[c:3]([NH2:12])[cH:4][cH:5][c:6]([Si:8]([CH3:9])([CH3:10])[CH3:11])[cH:7]1.[Li+:13]>>[F:1][c:2]1[c:3]([NH:12][c:24]2[c:25]([C:31](=[O:32])[OH:33])[n:26][cH:27][c:28]([Cl:30])[n:29]2)[cH:4][cH:5][c:6]([Si:8]([CH3:9])([CH3:10])[CH3:11])[cH:7]1Participants
6
Sources & evidence
- ORD record
- ord-e166418ba8164ea28fc2810c6b00ac06
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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