2-Propenoic acid, 3-phenyl-, methyl ester → methyl 3-phenyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-propanoate

HRID 300021Notes

Reaction equation

HRID 300021 reaction equation
[CH2:35]1[CH2:36][CH2:37][C:38]2=[N:43][CH2:42][CH2:41][CH2:40][N:39]2[CH2:44][CH2:45]1.[c:1]1([CH:7]=[CH:8][C:9](=[O:10])[O:11][CH3:12])[cH:2][cH:3][cH:4][cH:5][cH:6]1.[nH:13]1[n:14][cH:15][c:16](-[c:18]2[c:19]3[c:20]([n:21][cH:22][n:23]2)[n:24]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:32])([CH3:33])[CH3:34])[cH:25][cH:26]3)[cH:17]1>>[c:1]1([CH:7]([CH2:8][C:9](=[O:10])[O:11][CH3:12])[n:13]2[n:14][cH:15][c:16](-[c:18]3[c:19]4[c:20]([n:21][cH:22][n:23]3)[n:24]([CH2:27][O:28][CH2:29][CH2:30][Si:31]([CH3:32])([CH3:33])[CH3:34])[cH:25][cH:26]4)[cH:17]2)[cH:2][cH:3][cH:4][cH:5][cH:6]1

Participants

4

Reactant 3

HCID 76442-Propenoic acid, 3-phenyl-, methyl esterHCID 811841,8-Diazabicyclo(5.4.0)undec-7-eneHCID 426313464-(1H-Pyrazol-4-yl)-7-(2-(trimethylsilyl)ethoxy)methyl-7 H-pyrrolo(2,3-d)-pyrimidine

Product 1

HCID 57477997methyl 3-phenyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]-propanoate

Sources & evidence

ORD record
ord-c14d2ae49562454b8a496baecbb0ae25
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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