Water → Ethyl 4-(2-(4-tolylsulfanyl)phenyl)-piperidin-1-carboxylate

HRID 300263Notes

Reaction equation

HRID 300263 reaction equation
[CH2:8]([SiH:9]([CH2:10][CH3:11])[CH2:12][CH3:13])[CH3:14].[CH3:41][c:42]1[cH:43][cH:44][cH:45][cH:46][cH:47]1.[OH2:48].[OH:15][C:16]1([c:27]2[c:28]([S:33][c:34]3[cH:35][cH:36][c:37]([CH3:40])[cH:38][cH:39]3)[cH:29][cH:30][cH:31][cH:32]2)[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][CH2:25][CH3:26])[CH2:20][CH2:21]1.[OH:1][C:2]([C:3]([F:4])([F:5])[F:6])=[O:7]>>[CH:16]1([c:27]2[c:28]([S:33][c:34]3[cH:35][cH:36][c:37]([CH3:40])[cH:38][cH:39]3)[cH:29][cH:30][cH:31][cH:32]2)[CH2:17][CH2:18][N:19]([C:22](=[O:23])[O:24][CH2:25][CH3:26])[CH2:20][CH2:21]1

Participants

6

Reactant 5

HCID 962WaterHCID 1140TolueneHCID 6422Trifluoroacetic acidHCID 12052TriethylsilaneHCID 452583081-Carbethoxy-4-hydroxy-4-[2-(4-methylphenylsulfanyl)phenyl]piperidine

Product 1

HCID 45258309Ethyl 4-(2-(4-tolylsulfanyl)phenyl)-piperidin-1-carboxylate

Sources & evidence

ORD record
ord-23af4992fb764c1c841a6837483488dc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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