Hydrochloric Acid → Methyl 3-(4-{[2-(1H-indol-3-yl)-ethylamino]-methyl}-phenyl)-acrylate

HRID 301560Notes

Reaction equation

HRID 301560 reaction equation
[CH3:27][O:28][C:29]([CH:30]=[CH:31][c:32]1[cH:33][cH:34][c:35]([CH:38]=[O:39])[cH:36][cH:37]1)=[O:40].[CH3:41][OH:42].[CH:1]([c:2]1[cH:3][cH:4][c:5]([CH:6]=[CH:7][C:8]([OH:9])=[O:10])[cH:11][cH:12]1)=[O:13].[Cl:43][CH:44]([Cl:45])[CH3:46].[ClH:14].[K+:47].[K+:48].[NH2:15][CH2:16][CH2:17][c:18]1[cH:19][nH:20][c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]12.[O-:49][C:50]([O-:51])=[O:52]>>[NH:15]([CH2:16][CH2:17][c:18]1[cH:19][nH:20][c:21]2[cH:22][cH:23][cH:24][cH:25][c:26]12)[CH2:38][c:35]1[cH:34][cH:33][c:32]([CH:31]=[CH:30][C:29]([O:28][CH3:27])=[O:40])[cH:37][cH:36]1

Participants

9

Reactant 8

HCID 313Hydrochloric AcidHCID 813Potassium Cation2×HCID 887MethanolHCID 1150TryptamineHCID 63651,1-DichloroethaneHCID 19660Carbonate IonHCID 980772-Propenoic acid, 3-(4-formylphenyl)-HCID 53401287Methyl 3-(4-formylphenyl)-2-propenoate

Product 1

HCID 59036879Methyl 3-(4-{[2-(1H-indol-3-yl)-ethylamino]-methyl}-phenyl)-acrylate

Sources & evidence

ORD record
ord-03d2e0573f1d4c9eae8aec9384f3c41a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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