Acetate → N-methyl-N-(2,3,4,5,6-pentahydroxyhexyl)-6-{4-[3-[3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)-4-oxoazetidin-2-yl]phenyl}hex-5-enamide
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([CH:8]2[CH:9]([CH2:20][CH2:21][CH:22]([c:23]3[cH:24][cH:25][c:26]([F:29])[cH:27][cH:28]3)[O:30][Si:31]([CH3:32])([CH3:33])[C:34]([CH3:35])([CH3:36])[CH3:37])[C:10](=[O:19])[N:11]2[c:12]2[cH:13][cH:14][c:15]([F:18])[cH:16][cH:17]2)[cH:6][cH:7]1.[C:87]([O-:88])(=[O:89])[CH3:90].[C:92]([O-:93])(=[O:94])[CH3:95].[CH3:38][N:39]([C:40]([CH2:41][CH2:42][CH2:43][CH:44]=[CH2:45])=[O:46])[CH2:47][CH:48]([CH:49]([CH:50]([CH:51]([CH2:52][OH:53])[OH:54])[OH:55])[OH:56])[OH:57].[CH3:77][CH2:78][N:79]([CH2:80][CH3:81])[CH2:82][CH3:83].[Cl:84][CH2:85][Cl:86].[Pd+2:91].[c:58]1([P:59]([c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)[c:66]2[cH:67][cH:68][cH:69][cH:70][cH:71]2)[cH:72][cH:73][cH:74][cH:75][cH:76]1>>[c:2]1([CH:45]=[CH:44][CH2:43][CH2:42][CH2:41][C:40]([N:39]([CH3:38])[CH2:47][CH:48]([CH:49]([CH:50]([CH:51]([CH2:52][OH:53])[OH:54])[OH:55])[OH:56])[OH:57])=[O:46])[cH:3][cH:4][c:5]([CH:8]2[CH:9]([CH2:20][CH2:21][CH:22]([c:23]3[cH:24][cH:25][c:26]([F:29])[cH:27][cH:28]3)[O:30][Si:31]([CH3:32])([CH3:33])[C:34]([CH3:35])([CH3:36])[CH3:37])[C:10](=[O:19])[N:11]2[c:12]2[cH:13][cH:14][c:15]([F:18])[cH:16][cH:17]2)[cH:6][cH:7]1Participants
8
Reactant 7
HCID 175Acetate2×
HCID 6344Dichloromethane
HCID 8471Triethylamine
HCID 11776Triphenylphosphine
HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)
HCID 22252040N-methyl-N-(2,3,4,5,6-pentahydroxyhexyl)hex-5-enamide
HCID 222520774-(4-Bromophenyl)-3-[3-(tert-butyldimethylsilanyloxy)-3-(4-fluorophenyl)propyl]-1-(4-fluorophenyl)azetidin-2-oneProduct 1
Sources & evidence
- ORD record
- ord-9e9ada1309fd4ae7889150f04fdacf14
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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