Chloride → [5-(4-chloro-benzyloxy)-4-methoxy-pyridin-2-yl]-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol

HRID 301873Notes

Reaction equation

HRID 301873 reaction equation
[CH:22]([Mg+:23])([CH3:24])[CH3:25].[Cl-:21].[Cl:26][c:27]1[cH:28][cH:29][c:30]([CH2:31][O:32][c:33]2[c:34]([O:41][CH3:42])[cH:35][c:36]([CH:39]=[O:40])[n:37][cH:38]2)[cH:43][cH:44]1.[I:1][c:2]1[cH:3][n:4]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[c:5]2[n:6][cH:7][cH:8][cH:9][c:10]12.[O:45]1[CH2:46][CH2:47][CH2:48][CH2:49]1>>[c:2]1([CH:39]([c:36]2[cH:35][c:34]([O:41][CH3:42])[c:33]([O:32][CH2:31][c:30]3[cH:29][cH:28][c:27]([Cl:26])[cH:44][cH:43]3)[cH:38][n:37]2)[OH:40])[cH:3][n:4]([Si:11]([CH:12]([CH3:13])[CH3:14])([CH:15]([CH3:16])[CH3:17])[CH:18]([CH3:19])[CH3:20])[c:5]2[n:6][cH:7][cH:8][cH:9][c:10]12

Participants

6

Reactant 5

HCID 312ChlorideHCID 8028TetrahydrofuranHCID 242292273-Iodo-1-[tris(1-methylethyl)silyl]-1H-pyrrolo[2,3-b]pyridineHCID 580874295-(4-Chloro-benzyloxy)-4-methoxy-pyridine-2-carbaldehydeHCID 178461726HCID 178461726, compound

Product 1

HCID 58087829[5-(4-chloro-benzyloxy)-4-methoxy-pyridin-2-yl]-(1-triisopropylsilanyl-1H-pyrrolo[2,3-b]pyridin-3-yl)-methanol

Sources & evidence

ORD record
ord-6f3902264b2d488ab943b6f2f9cff3ab
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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