Bromide ion → 1-[2-(4-Trifluoromethyl-phenyl)-4-(4-trifluoromethyl-piperidin-1-ylmethyl)-thiazol-5-yl]-propan-1-ol
Reaction equation
[Br-:29].[CH2:30]([CH3:31])[Mg+:32].[CH3:44][O:45][C:46]([CH3:47])([CH3:48])[CH3:49].[F:1][C:2]([c:3]1[cH:4][cH:5][c:6](-[c:9]2[s:10][c:11]([CH:25]=[O:26])[c:12]([CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([C:21]([F:22])([F:23])[F:24])[CH2:19][CH2:20]3)[n:13]2)[cH:7][cH:8]1)([F:27])[F:28].[K+:38].[O:39]1[CH2:40][CH2:41][CH2:42][CH2:43]1.[P:33]([O-:34])([OH:35])([OH:36])=[O:37]>>[F:1][C:2]([c:3]1[cH:4][cH:5][c:6](-[c:9]2[s:10][c:11]([CH:25]([OH:26])[CH2:30][CH3:31])[c:12]([CH2:14][N:15]3[CH2:16][CH2:17][CH:18]([C:21]([F:22])([F:23])[F:24])[CH2:19][CH2:20]3)[n:13]2)[cH:7][cH:8]1)([F:27])[F:28]Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-e1fa76c0275f4adabc8c5973d9ee94a5
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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