Piperazine → N-[5-chloro-7-(3-methoxyprop-1-yn-1-yl)-1,3-benzodioxol-4-yl]-6-methoxy-7-[3-piperazin-1-ylpropoxy]-quinazolin-4-amine
Reaction equation
[CH2:34]1[CH2:35][NH:36][CH2:37][CH2:38][NH:39]1.[CH3:40][O:41][CH2:42][CH2:43][OH:44].[Cl:1][c:2]1[c:3]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][c:23]([O:29][CH2:30][CH2:31][CH2:32][Cl:33])[c:24]([O:27][CH3:28])[cH:25][c:26]23)[c:4]2[c:5]([c:9]([C:11]#[C:12][CH2:13][O:14][CH3:15])[cH:10]1)[O:6][CH2:7][O:8]2.[Cl:45][CH2:46][Cl:47]>>[Cl:1][c:2]1[c:3]([NH:16][c:17]2[n:18][cH:19][n:20][c:21]3[cH:22][c:23]([O:29][CH2:30][CH2:31][CH2:32][N:36]4[CH2:35][CH2:34][NH:39][CH2:38][CH2:37]4)[c:24]([O:27][CH3:28])[cH:25][c:26]23)[c:4]2[c:5]([c:9]([C:11]#[C:12][CH2:13][O:14][CH3:15])[cH:10]1)[O:6][CH2:7][O:8]2Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-48f647963c174d3d92298341b8566ad3
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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