Ammonium → N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

HRID 303661Notes

Reaction equation

HRID 303661 reaction equation
[BH4-:1].[CH3:38][CH2:39][OH:40].[CH3:3][OH:4].[CH3:41][CH2:42][O:43][C:44](=[O:45])[CH3:46].[Cl-:36].[F:5][c:6]1[c:7]([NH:29][C:30](=[O:31])[C:32]([F:33])([F:34])[F:35])[cH:8][c:9]([N:12]([c:13]2[cH:14][cH:15][c:16]3[c:17]([n:18]2)[s:19][c:20]([NH:22][C:23](=[O:24])[CH:25]2[CH2:26][CH2:27]2)[n:21]3)[CH3:28])[cH:10][cH:11]1.[NH4+:37].[Na+:2]>>[F:5][c:6]1[c:7]([NH2:29])[cH:8][c:9]([N:12]([c:13]2[cH:14][cH:15][c:16]3[c:17]([n:18]2)[s:19][c:20]([NH:22][C:23](=[O:24])[CH:25]2[CH2:26][CH2:27]2)[n:21]3)[CH3:28])[cH:10][cH:11]1

Participants

9

Reactant 8

HCID 223AmmoniumHCID 312ChlorideHCID 702EthanolHCID 887MethanolHCID 923Sodium ionHCID 8857Ethyl AcetateHCID 28123BorohydrideHCID 86646058N-[5-[{4-fluoro-3-[(trifluoroacetyl)amino]phenyl}(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl]cyclopropanecarboxamide

Product 1

HCID 86646059N-{5-[(3-amino-4-fluorophenyl)(methyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

Sources & evidence

ORD record
ord-6ed5466eb2f24db69797d058904e7984
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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