Water → Tert-butyl 2-cyano-4-hydroxy-pyrrolidine-1-carboxylate

HRID 304333Notes

Reaction equation

HRID 304333 reaction equation
[CH3:31][CH2:32][O:33][C:34](=[O:35])[CH3:36].[F:17][C:18]([F:19])([F:20])[C:21]([O:22][C:23](=[O:24])[C:25]([F:26])([F:27])[F:28])=[O:29].[NH2:1][C:2](=[O:3])[CH:4]1[N:5]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:6][CH:7]([OH:9])[CH2:8]1.[OH2:30].[cH:37]1[cH:38][cH:39][n:40][cH:41][cH:42]1>>[N:1]#[C:2][CH:4]1[N:5]([C:10](=[O:11])[O:12][C:13]([CH3:14])([CH3:15])[CH3:16])[CH2:6][CH:7]([OH:9])[CH2:8]1

Participants

6

Reactant 5

HCID 962WaterHCID 1049PyridineHCID 8857Ethyl AcetateHCID 9845Trifluoroacetic anhydrideHCID 14796647Tert-butyl 2-carbamoyl-4-hydroxypyrrolidine-1-carboxylate

Product 1

HCID 68626765Tert-butyl 2-cyano-4-hydroxy-pyrrolidine-1-carboxylate

Sources & evidence

ORD record
ord-78b9776e3ecd487db6d95a57d1e4470a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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