4-Methylmorpholine → 2-bromo-N-(7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)isonicotinamide

HRID 304413Notes

Reaction equation

HRID 304413 reaction equation
[Br:1][c:2]1[cH:3][c:4]([C:5](=[O:6])[OH:7])[cH:8][cH:9][n:10]1.[CH2:60]1[O:61][CH2:62][CH2:63][CH2:64]1.[CH3:35][N:36]1[CH2:37][CH2:38][O:39][CH2:40][CH2:41]1.[CH3:42][O:43][c:44]1[c:45]2[c:46]([c:47]([N:50]3[CH2:51][CH2:52][O:53][CH2:54][CH2:55]3)[n:48][cH:49]1)[s:56][c:57]([NH2:59])[n:58]2.[P-:11]([F:12])([F:13])([F:14])([F:15])([F:16])[F:17].[n:18]1([O:19][C:20]([N:21]([CH3:22])[CH3:23])=[N+:24]([CH3:25])[CH3:26])[c:27]2[n:28][cH:29][cH:30][cH:31][c:32]2[n:33][n:34]1>>[Br:1][c:2]1[cH:3][c:4]([C:5](=[O:7])[NH:59][c:57]2[s:56][c:46]3[c:45]([c:44]([O:43][CH3:42])[cH:49][n:48][c:47]3[N:50]3[CH2:51][CH2:52][O:53][CH2:54][CH2:55]3)[n:58]2)[cH:8][cH:9][n:10]1

Participants

7

Reactant 6

HCID 79724-MethylmorpholineHCID 8028TetrahydrofuranHCID 9886HexafluorophosphateHCID 2227012-Bromoisonicotinic acidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 860385537-Methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-ylamine

Product 1

HCID 865972552-bromo-N-(7-methoxy-4-morpholin-4-yl-thiazolo[5,4-c]pyridin-2-yl)isonicotinamide

Sources & evidence

ORD record
ord-b61fd06e04c5481d814ef7c710e14dd3
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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