反应详情

5-Bromo-pyridine-3-carbaldehyde (0.190g, 1 mmol), NaB(OAc)3H (0.320 g, 1.50 mmol) and piperidine (0.090 g, 1.05 mmol) were suspended in DCM (8 mL) and the reaction mixture was stirred overnight at rt. The reaction was quenched by the addition of 1 M NaOH solution (5 mL) and the mixture was stirred for 1 h. The reaction mixture was extracted with DCM (3×15 mL). The organic extracts were combined, dried over Na2SO4, filtered, and concentrated to yield a crude oily product (0.18 g, 71%). This crude product was carried to the next step.

1. customThe reaction was quenched by the addition of 1 M NaOH solution (5 mL)
2. stirringthe mixture was stirred for 1 h
3. extractionThe reaction mixture was extracted with DCM (3×15 mL)
4. dry with materialdried over Na2SO4
5. filtrationfiltered
6. concentrationconcentrated