Dimethyl Sulfoxide → 2,2-Dimethyl-4-oxo-4-(3-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenoxy}-piperidin-1-yl)-butyric acid

HRID 304928Notes

Reaction equation

HRID 304928 reaction equation
[CH3:32][C:33]1([CH3:40])[C:34](=[O:39])[O:35][C:36](=[O:38])[CH2:37]1.[CH3:41][CH2:42][N:43]([CH2:44][CH3:45])[CH2:46][CH3:47].[CH3:48][S:49]([CH3:50])=[O:51].[CH3:52][CH2:53][O:54][C:55](=[O:56])[CH3:57].[NH:1]1[CH2:2][CH:3]([O:7][c:8]2[cH:9][cH:10][c:11]([NH:14][C:15](=[O:16])[c:17]3[n:18][c:19](-[c:26]4[cH:27][cH:28][cH:29][cH:30][cH:31]4)[o:20][c:21]3[C:22]([F:23])([F:24])[F:25])[cH:12][cH:13]2)[CH2:4][CH2:5][CH2:6]1>>[N:1]1([C:36]([CH2:37][C:33]([CH3:32])([C:34](=[O:35])[OH:39])[CH3:40])=[O:38])[CH2:2][CH:3]([O:7][c:8]2[cH:9][cH:10][c:11]([NH:14][C:15](=[O:16])[c:17]3[n:18][c:19](-[c:26]4[cH:27][cH:28][cH:29][cH:30][cH:31]4)[o:20][c:21]3[C:22]([F:23])([F:24])[F:25])[cH:12][cH:13]2)[CH2:4][CH2:5][CH2:6]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 870672,2-Dimethylsuccinic anhydrideHCID 576518792-Phenyl-5-trifluoromethyl-oxazole-4-carboxylic acid [4-(piperidin-3-yloxy)-phenyl]-amide

Product 1

HCID 251229272,2-Dimethyl-4-oxo-4-(3-{4-[(2-phenyl-5-trifluoromethyl-oxazole-4-carbonyl)-amino]-phenoxy}-piperidin-1-yl)-butyric acid

Sources & evidence

ORD record
ord-8f9315615bfe45d5bb2b309faf893854
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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