反应详情

3-{Ethoxycarbonylmethyl-[6-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoyl]-amino}-propionic acid ethyl ester AB (11.5 g, 21.3 mmol) was dissolved in 20% piperidine in dimethylformamide at 0° C. The solution was continued stirring for 1 h. The reaction mixture was concentrated under vacuum, water was added to the residue, and the product was extracted with ethyl acetate. The crude product was purified by conversion into its hydrochloride salt.

1. concentrationThe reaction mixture was concentrated under vacuum, water
2. additionwas added to the residue
3. extractionthe product was extracted with ethyl acetate
4. customThe crude product was purified by conversion into its hydrochloride salt