Tetrahydrofuran → N-(2,3-dihydroxy-propoxy)-3,4-difluoro-2-(2-fluoro-phenylamino)-benzamide
Reaction equation
[CH3:27][CH2:28][N:29]([CH2:30][CH3:31])[CH2:32][CH3:33].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1.[OH:1][CH:2]([CH2:3][O:4][NH:5][C:6]([c:7]1[c:8]([NH:15][c:16]2[c:17]([F:23])[cH:18][c:19]([I:22])[cH:20][cH:21]2)[c:9]([F:14])[c:10]([F:13])[cH:11][cH:12]1)=[O:24])[CH2:25][OH:26]>>[OH:1][CH:2]([CH2:3][O:4][NH:5][C:6]([c:7]1[c:8]([NH:15][c:16]2[c:17]([F:23])[cH:18][cH:19][cH:20][cH:21]2)[c:9]([F:14])[c:10]([F:13])[cH:11][cH:12]1)=[O:24])[CH2:25][OH:26]Participants
4
Sources & evidence
- ORD record
- ord-07975cdd650e4bba90521ef6b6075b8a
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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