(4-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-yl)methanol → HCID 85969110, compound

HRID 30706Notes

Reaction equation

HRID 30706 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[N:10][N:11]([CH3:15])[C:12]=2[CH2:13][OH:14])=[CH:4][CH:3]=1>[O-2].[O-2].[Mn+4].O1CCCC1>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:9]=[N:10][N:11]([CH3:15])[C:12]=2[CH:13]=[O:14])=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 69207780(4-(4-Fluorophenyl)-1-methyl-1H-pyrazol-5-yl)methanol

Product 1

HCID 85969110HCID 85969110, compoundYield 70%

Reagents, catalysts & solvents 2

HCID 178418406HCID 178418406, compoundCatalystHCID 8028TetrahydrofuranSolvent

Procedure

A mixture of [4-(4-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]methanol (250 mg), activated manganese dioxide (1.0 g) and tetrahydrofuran (10 ml) was stirred at room temperature for 3 hrs. The reaction mixture was filtered, and the organic layer was concentrated to give 4-(4-fluorophenyl)-1-methyl-1H-pyrazole-5-carbaldehyde (172 mg, yield 70%) as pale-yellow crystals.

Workup

  1. filtrationThe reaction mixture was filtered
  2. concentrationthe organic layer was concentrated

Sources & evidence

ORD record
ord-1e93fb7e727246f5890a765717768e33
Source dataset
uspto-grants-2008_09
Patent number
US07423159B2

Reaction notes

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