Water → Tert-butyl 3-(2-(3-(trifluoromethyl)-1,6-naphthyridin-5-ylamino)acetamido)azetidine-1-carboxylate

HRID 307115Notes

Reaction equation

HRID 307115 reaction equation
[CH3:32][CH2:33][N:34]([CH2:35][CH3:36])[CH2:37][CH3:38].[CH3:39][O:40][CH2:41][CH2:42][O:43][CH2:44][CH2:45][O:46][CH3:47].[Cl:1][c:2]1[c:3]2[cH:4][c:5]([C:12]([F:13])([F:14])[F:15])[cH:6][n:7][c:8]2[cH:9][cH:10][n:11]1.[NH2:16][CH2:17][C:18](=[O:19])[NH:20][CH:21]1[CH2:22][N:23]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:24]1.[OH2:48]>>[c:2]1([NH:16][CH2:17][C:18](=[O:19])[NH:20][CH:21]2[CH2:22][N:23]([C:25](=[O:26])[O:27][C:28]([CH3:29])([CH3:30])[CH3:31])[CH2:24]2)[c:3]2[cH:4][c:5]([C:12]([F:13])([F:14])[F:15])[cH:6][n:7][c:8]2[cH:9][cH:10][n:11]1

Participants

6

Reactant 5

HCID 962WaterHCID 8150DiglymeHCID 8471TriethylamineHCID 18699815Tert-butyl 3-(2-aminoacetamido)azetidine-1-carboxylateHCID 585627455-Chloro-3-(trifluoromethyl)-1,6-naphthyridine

Product 1

HCID 68003927Tert-butyl 3-(2-(3-(trifluoromethyl)-1,6-naphthyridin-5-ylamino)acetamido)azetidine-1-carboxylate

Sources & evidence

ORD record
ord-dfb9a5ccc3ca4cdeaca6fa36762cd211
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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