Hydrochloric Acid → HCID 69205646, compound

HRID 30713Notes

Reaction equation

HRID 30713 reaction equation
C([O:3][C:4]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13][C:14](=[O:34])[CH2:15][CH2:16][C:17]2[CH:18]=[N:19][N:20]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[C:21]=2[C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)=[CH:9][CH:8]=1)=[O:5])C.[OH-].[Na+].Cl>C(O)C>[C:28]1([N:20]2[C:21]([C:22]3[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=3)=[C:17]([CH2:16][CH2:15][C:14]([NH:13][C:10]3[CH:9]=[CH:8][C:7]([CH2:6][C:4]([OH:5])=[O:3])=[CH:12][CH:11]=3)=[O:34])[CH:18]=[N:19]2)[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 69207828N-[4-(ethoxycarbonylmethyl)phenyl]-3-(1,5-diphenyl-1H-pyrazol-4-yl)propionamide

Product 1

HCID 69205646HCID 69205646, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of N-[4-(ethoxycarbonylmethyl)phenyl]-3-(1,5-diphenyl-1H-pyrazol-4-yl)propionamide (0.76 g), a 1N aqueous sodium hydroxide solution (5 ml) and ethanol (5 ml) was stirred at 50° C. for 3 hrs. The reaction mixture was poured into a 1N aqueous hydrochloric acid solution and the precipitated crystals were collected by filtration, washed with water and dried to give (4-{[3-(1,5-diphenyl-1H-pyrazol-4-yl)propanoyl]amino}phenyl)acetic acid.

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. washwashed with water
  3. customdried

Sources & evidence

ORD record
ord-fd80a2d9bc6145b3915857d7ca3679ed
Source dataset
uspto-grants-2008_09
Patent number
US07423159B2

Reaction notes

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