Tetrahydrofuran → N-methyl-3-(m-trifluoromethylphenyl)-piperidine
Reaction equation
[Al+3:2].[F:7][C:8]([c:9]1[cH:10][c:11]([CH:15]2[CH2:16][N:17]([CH:21]=[O:22])[CH2:18][CH2:19][CH2:20]2)[cH:12][cH:13][cH:14]1)([F:23])[F:24].[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3].[O:25]1[CH2:26][CH2:27][CH2:28][CH2:29]1>>[F:7][C:8]([c:9]1[cH:10][c:11]([CH:15]2[CH2:16][N:17]([CH3:21])[CH2:18][CH2:19][CH2:20]2)[cH:12][cH:13][cH:14]1)([F:23])[F:24]Participants
6
Sources & evidence
- ORD record
- ord-7c3c0d39e5e449688af158fbfcb77074
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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