Tetrahydrofuran → 6-(2,4-Difluoro-phenyl)-5-{hydroxy-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methyl}-naphthalen-2-ol

HRID 307563Notes

Reaction equation

HRID 307563 reaction equation
[Al+3:38].[CH2:43]1[O:44][CH2:45][CH2:46][CH2:47]1.[F:1][c:2]1[c:3](-[c:9]2[c:10]([C:20](=[O:21])[c:22]3[cH:23][cH:24][c:25]([O:28][CH2:29][CH2:30][N:31]4[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]4)[cH:26][cH:27]3)[c:11]3[cH:12][cH:13][c:14]([OH:19])[cH:15][c:16]3[cH:17][cH:18]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1.[H-:37].[H-:40].[H-:41].[H-:42].[Li+:39]>>[F:1][c:2]1[c:3](-[c:9]2[c:10]([CH:20]([OH:21])[c:22]3[cH:23][cH:24][c:25]([O:28][CH2:29][CH2:30][N:31]4[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]4)[cH:26][cH:27]3)[c:11]3[cH:12][cH:13][c:14]([OH:19])[cH:15][c:16]3[cH:17][cH:18]2)[cH:4][cH:5][c:6]([F:8])[cH:7]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 67004951[2-(2,4-Difluoro-phenyl)-6-hydroxy-naphthalen-1-yl]-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methanone

Product 1

HCID 670047256-(2,4-Difluoro-phenyl)-5-{hydroxy-[4-(2-piperidin-1-yl-ethoxy)-phenyl]-methyl}-naphthalen-2-ol

Sources & evidence

ORD record
ord-eea1e1356a274ef9a15ba5a86c3a4320
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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