反应详情

温度

20 °C

A flask was flame dried and placed under a nitrogen atmosphere. 1-methylpiperidine-4-carboxylic acid (1 eq) in anhydrous methylene chloride added to flask and cooled to 20° C. in a water bath. Dimethylformamide added, then oxalyl chloride (1.4 eq) in methylene chloride. Reaction refluxed for 2 hours, brought to room temperature, concentrated and azeotroped with toluene to yield 1-methylpiperidine-4-carbonyl chloride as a light yellow fluffy solid. MS: MH+=162.

1. temperatureA flask was flame
2. customdried
3. customReaction
4. temperaturerefluxed for 2 hours
5. custombrought to room temperature
6. concentrationconcentrated
7. customazeotroped with toluene