Tetrahydrofuran → 2-{4-[2-Dimethylaminomethyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester

HRID 308519Notes

Reaction equation

HRID 308519 reaction equation
[CH2:23]([CH3:24])[O:25][C:26]([C:27]([CH3:28])([CH3:29])[O:30][c:31]1[c:32]([CH3:38])[cH:33][c:34]([OH:37])[cH:35][cH:36]1)=[O:39].[CH2:40]([P:41]([CH2:42][CH2:43][CH2:44][CH3:45])[CH2:46][CH2:47][CH2:48][CH3:49])[CH2:50][CH2:51][CH3:52].[CH2:53]1[O:54][CH2:55][CH2:56][CH2:57]1.[CH3:1][N:2]([CH3:3])[CH2:4][c:5]1[n:6][c:7](-[c:13]2[cH:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]2)[cH:8][cH:9][c:10]1[CH2:11][OH:12]>>[CH3:1][N:2]([CH3:3])[CH2:4][c:5]1[n:6][c:7](-[c:13]2[cH:14][cH:15][c:16]([C:19]([F:20])([F:21])[F:22])[cH:17][cH:18]2)[cH:8][cH:9][c:10]1[CH2:11][O:12][c:34]1[cH:33][c:32]([CH3:38])[c:31]([O:30][C:27]([C:26]([O:25][CH2:23][CH3:24])=[O:39])([CH3:28])[CH3:29])[cH:36][cH:35]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 13831TributylphosphineHCID 16756990Ethyl 2-(4-hydroxy-2-methylphenoxy)-2-methylpropanoateHCID 21935887HCID 21935887, compound

Product 1

HCID 670722672-{4-[2-Dimethylaminomethyl-6-(4-trifluoromethyl-phenyl)-pyridin-3-ylmethoxy]-2-methyl-phenoxy}-2-methyl-propionic acid ethyl ester

Sources & evidence

ORD record
ord-a78465a45eaf4d308a95a9f448a52ff6
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…