Tetrahydrofuran → 7-chloro-3-{1-[2-(5-amino-2-methylphenyl)ethyl]piperidin-4-yl}-1H-indole
Reaction equation
[Al+3:2].[Cl:7][c:8]1[cH:9][cH:10][cH:11][c:12]2[c:13]([CH:17]3[CH2:18][CH2:19][N:20]([C:23]([CH2:24][c:25]4[c:26]([CH3:32])[cH:27][cH:28][c:29]([NH2:31])[cH:30]4)=[O:33])[CH2:21][CH2:22]3)[cH:14][nH:15][c:16]12.[H-:1].[H-:4].[H-:5].[H-:6].[Li+:3].[O:34]1[CH2:35][CH2:36][CH2:37][CH2:38]1>>[Cl:7][c:8]1[cH:9][cH:10][cH:11][c:12]2[c:13]([CH:17]3[CH2:18][CH2:19][N:20]([CH2:23][CH2:24][c:25]4[c:26]([CH3:32])[cH:27][cH:28][c:29]([NH2:31])[cH:30]4)[CH2:21][CH2:22]3)[cH:14][nH:15][c:16]12Participants
6
Sources & evidence
- ORD record
- ord-46b43ef15c5748b29b233921f48587aa
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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