反应详情

In a round-bottomed flask fitted with a Vigreux column, a reflux divider and a condenser, 77.08 g (0.70 mol.) of resorcinol are dissolved, under argon, in 250 ml of dry pyridine. 84.3 g of sodium methoxide solution in methanol (30% solution) are added dropwise to the reaction mixture, with stirring. Methanol is then removed from the reaction mixture by distillation. The reflux divider is then closed and 261.9 g (1.40 mol.) of 3-bromoanisole are added dropwise. 3.5 g (0.04 mol.) of CuCl are also added. The mixture is allowed to boil under reflux for 6 hours. Pyridine is then distilled off via the opened reflux divider, during which the sump temperature rises to 150° C. The mixture is then allowed to cool and the residue is stirred into 250 ml of semi-concentrated hydrochloric acid. The mixture is extracted with 300 ml of toluene. The organic phase is washed first with semi-concentrated hydrochloric acid and then a further two times with NaOH solution (10%). The combined alkaline phases are acidified with dilute HCl and extracted with a diethyl ether/toluene mixture (1:1). After removal of the solvent, 65.5 g of a brown oil are obtained.

1. customIn a round-bottomed flask fitted with a Vigreux column
2. customMethanol is then removed from the reaction mixture by distillation
3. customThe reflux divider is then closed
4. temperatureunder reflux for 6 hours
5. distillationPyridine is then distilled off via the
6. temperatureopened reflux divider
7. customrises to 150° C
8. temperatureto cool
9. stirringthe residue is stirred into 250 ml of semi-concentrated hydrochloric acid
10. extractionThe mixture is extracted with 300 ml of toluene
11. washThe organic phase is washed first with semi-concentrated hydrochloric acid
12. extractionextracted with a diethyl ether/toluene mixture (1:1)
13. customAfter removal of the solvent, 65.5 g of a brown oil
14. customare obtained