Tetrahydrofuran → (4-methyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-4-yl)methanamine

HRID 310419Notes

Reaction equation

HRID 310419 reaction equation
[Al+3:23].[CH2:28]1[O:29][CH2:30][CH2:31][CH2:32]1.[CH3:1][C:2]1([C:20]#[N:21])[CH2:3][CH2:4][CH2:5][c:6]2[c:7]1[n:8][c:9](-[c:11]1[c:12]3[c:13]([n:14][cH:15][cH:16]1)[nH:17][n:18][cH:19]3)[s:10]2.[H-:22].[H-:25].[H-:26].[H-:27].[Li+:24]>>[CH3:1][C:2]1([CH2:20][NH2:21])[CH2:3][CH2:4][CH2:5][c:6]2[c:7]1[n:8][c:9](-[c:11]1[c:12]3[c:13]([n:14][cH:15][cH:16]1)[nH:17][n:18][cH:19]3)[s:10]2

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 66645490HCID 66645490, compound

Product 1

HCID 49800491(4-methyl-2-(1H-pyrazolo[3,4-b]pyridin-4-yl)-4,5,6,7-tetrahydrobenzo[d]thiazol-4-yl)methanamine

Sources & evidence

ORD record
ord-9830ef81a9394f20a5eed37ef774dd7c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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