1,2-Dichloroethane → 6-(Methyloxy)-7-nitro-2-(1-propyl-4-piperidinyl)-1,2,3,4-tetrahydroisoquinoline

HRID 310638Notes

Reaction equation

HRID 310638 reaction equation
[C:30]([O:31][BH-:32]([O:33][C:34](=[O:35])[CH3:36])[O:37][C:38](=[O:39])[CH3:40])(=[O:41])[CH3:42].[CH2:1]([CH2:2][CH3:3])[N:4]1[CH2:5][CH2:6][C:7](=[O:10])[CH2:8][CH2:9]1.[CH3:11][O:12][c:13]1[cH:14][c:15]2[c:20]([cH:21][c:22]1[N+:23](=[O:24])[O-:25])[CH2:19][NH:18][CH2:17][CH2:16]2.[CH3:26][C:27](=[O:28])[OH:29].[CH3:48][CH2:49][N:50]([CH2:51][CH3:52])[CH2:53][CH3:54].[Cl:44][CH2:45][CH2:46][Cl:47].[Na+:43]>>[CH2:1]([CH2:2][CH3:3])[N:4]1[CH2:5][CH2:6][CH:7]([N:18]2[CH2:17][CH2:16][c:15]3[cH:14][c:13]([O:12][CH3:11])[c:22]([N+:23](=[O:24])[O-:25])[cH:21][c:20]3[CH2:19]2)[CH2:8][CH2:9]1

Participants

8

Reactant 7

HCID 111,2-DichloroethaneHCID 176Acetic AcidHCID 923Sodium ionHCID 8471TriethylamineHCID 900061-Propyl-4-piperidoneHCID 2724942TriacetoxyborohydrideHCID 594418746-Methoxy-7-nitro-1,2,3,4-tetrahydroisoquinoline

Product 1

HCID 594416526-(Methyloxy)-7-nitro-2-(1-propyl-4-piperidinyl)-1,2,3,4-tetrahydroisoquinoline

Sources & evidence

ORD record
ord-3c42fa477b9248aab59290c0f383d051
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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