Tetrahydrofuran → 2,6-dichloro-N-[1-[2-(2,6-dichlorophenyl)quinolin-6-yl]-3-hydroxypropan-2-yl]benzamide

HRID 310862Notes

Reaction equation

HRID 310862 reaction equation
[Al+3:37].[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[Cl:1][c:2]1[c:3]([C:4](=[O:5])[NH:6][CH:7]([C:8](=[O:9])[O:10][CH3:11])[CH2:12][c:13]2[cH:14][c:15]3[cH:16][cH:17][c:18](-[c:23]4[c:24]([Cl:30])[cH:25][cH:26][cH:27][c:28]4[Cl:29])[n:19][c:20]3[cH:21][cH:22]2)[c:31]([Cl:35])[cH:32][cH:33][cH:34]1.[H-:36].[H-:39].[H-:40].[H-:41].[Li+:38]>>[Cl:1][c:2]1[c:3]([C:4](=[O:5])[NH:6][CH:7]([CH2:8][OH:9])[CH2:12][c:13]2[cH:14][c:15]3[cH:16][cH:17][c:18](-[c:23]4[c:24]([Cl:30])[cH:25][cH:26][cH:27][c:28]4[Cl:29])[n:19][c:20]3[cH:21][cH:22]2)[c:31]([Cl:35])[cH:32][cH:33][cH:34]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 10482608methyl N-(2,6-dichlorobenzoyl)-3-[2-(2,6-dichlorophenyl)-6-quinolyl]alaninate

Product 1

HCID 579876272,6-dichloro-N-[1-[2-(2,6-dichlorophenyl)quinolin-6-yl]-3-hydroxypropan-2-yl]benzamide

Sources & evidence

ORD record
ord-14bdc0e3b7854783a28d9f34d75bbdc2
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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