Dimethyl Sulfoxide → Tert-butyl 4-(chloromethyl)-4-formylpiperidine-1-carboxylate

HRID 311237Notes

Reaction equation

HRID 311237 reaction equation
[CH3:28][CH2:29][N:30]([CH2:31][CH3:32])[CH2:33][CH3:34].[CH3:7][S:8]([CH3:9])=[O:10].[Cl:11][CH2:12][C:13]1([CH2:26][OH:27])[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]1.[Cl:1][C:2]([C:3]([Cl:4])=[O:5])=[O:6].[Cl:35][CH2:36][Cl:37]>>[Cl:11][CH2:12][C:13]1([CH:26]=[O:27])[CH2:14][CH2:15][N:16]([C:19](=[O:20])[O:21][C:22]([CH3:23])([CH3:24])[CH3:25])[CH2:17][CH2:18]1

Participants

6

Reactant 5

HCID 679Dimethyl SulfoxideHCID 6344DichloromethaneHCID 8471TriethylamineHCID 65578Oxalyl chlorideHCID 67411808Tert-butyl 4-(chloromethyl)-4-(hydroxymethyl)piperidine-1-carboxylate

Product 1

HCID 53392200Tert-butyl 4-(chloromethyl)-4-formylpiperidine-1-carboxylate

Sources & evidence

ORD record
ord-8dc5deba8d6a40c282b7e40a0a8158db
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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