Ethanol → 3-[2-(4-[2-Pyridyl]phenyl)ethynyl]-3-hydroxyquinuclidine

HRID 311496Notes

Reaction equation

HRID 311496 reaction equation
[Br:12][c:13]1[cH:14][cH:15][c:16](-[c:19]2[n:20][cH:21][cH:22][cH:23][cH:24]2)[cH:17][cH:18]1.[C:1](#[CH:2])[C:3]1([OH:11])[CH2:4][N:5]2[CH2:6][CH2:7][CH:8]1[CH2:9][CH2:10]2.[CH2:38]([OH:39])[CH3:40].[CH3:25][N:26]([CH3:27])[CH:28]=[O:29].[CH3:32][CH2:33][CH2:34][CH2:35][CH2:36][CH3:37].[Cu:30][I:31]>>[C:1](#[C:2][c:13]1[cH:14][cH:15][c:16](-[c:19]2[n:20][cH:21][cH:22][cH:23][cH:24]2)[cH:17][cH:18]1)[C:3]1([OH:11])[CH2:4][N:5]2[CH2:6][CH2:7][CH:8]1[CH2:9][CH2:10]2

Participants

7

Reactant 6

HCID 702EthanolHCID 6228DimethylformamideHCID 8058HexaneHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 15152372-(4-Bromophenyl)pyridineHCID 36135173-Ethynyl-1-azabicyclo[2.2.2]octan-3-ol

Product 1

HCID 197031613-[2-(4-[2-Pyridyl]phenyl)ethynyl]-3-hydroxyquinuclidine

Sources & evidence

ORD record
ord-2b750229cd4e48b682d921991c15a84c
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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